Scott Strome
University of Maryland School of Medicine. USA.
Title: Manipulation of the B7-H1 (PD-L1)-PD-1 Axis for the Treatment of Head and Neck Cancer: A Personal Perspective.
Biography
Biography: Scott Strome
Abstract
The ability to block PD-1:PD-L1 interactions has altered our approach to the management of many solid malignancies including head and neck cancer. Despite the success of these therapies, many Otolaryngologists-Head and Neck Surgeons have only limited familiarity with the role of such immuno-oncologic strategies in the management of head and neck cancer. In this talk, Dr. Strome – an inventor of PD-L1 blockade for the treatment of cancer -- will describe some of the original work that identified the PD-1:PD-L1 pathway as a target for cancer therapy, the current role of anti-PD-1/PD-L1 blocking antibodies in the management of head and neck cancer, and potential future directions for manipulating co-signaling pathways for Head and Neck cancer therapy.