3^rd European Otolaryngology-ENT Surgery Conference

The purpose of this presentation is to report voice and oncologic results from a cohort of patients with early glottic cancer who were treated with ultra-narrow margins using angiolytic KTP laser surgery. Wound healing after transoral angiolytic laser surgery for early glottic carcinoma was analyzed to identify factors influencing healing and clinical significance of persistent granulation tissue. A cohort of 117 patients (T1a-71, T1b-11, T2a-10, T2b-25) underwent KTP laser treatment of early glottic cancer with a minimum 4-year follow up. Pre-treatment and post-treatment voice outcome data were obtained in 72/117 patients. Evaluations included objective measures (acoustic and aerodynamic) and Voice-Related Quality of Life survey (VRQOL). Disease control for T1 and T2 lesions was 96% (79/82) and 80% (28/35) respectively. All 10 recurrences were treated with radiotherapy. Larynx preservation and survival were achieved in 99% (81/82) with T1 disease and 89% (31/35) with T2 disease. There were statistically significant post-operative improvements for acoustic measures of voice quality (perturbation and signal-to-noise) and self-assessments of vocal function for both groups. Angiolytic KTP laser treatment of early glottic cancer is an effective treatment for early glottic cancer. Oncologic results compare favorably with other reported series and voice results show excellent preservation of glottic function. Most vocal fold wounds heal completely within 3 months after angiolytic laser surgery for early glottic carcinoma. Larger and deeper wounds are more likely to heal with granulation tissue.Granulation can resolve without surgical intervention; however, granulation present >3 months warrants biopsy due to

increased risk of malignancy.